Table of Contents

I. Migraine: History
Chapter 1: A History of Migraine, Mervyn Eadie

II. Neurobiology of the Migraine Brain
Chapter 2: Migraine - Some Theories and Controversies, Farooq Maniyar and Peter J. Goadsby

Chapter 3: Neural System Changes in Migraine, Peter D. Drummond

Chapter 4: Sensitization of Trigeminovascular Pathway: Implications to Migraine Pathophysiology, Rami Burstein and David Borsook

Chapter 5: Brain Measures of the Interictal Migraine Brain State (IMBS), Nasim Maleki, Lino Becerra, and David Borsook

Chapter 6: From Episodic to Chronic Migraine, Richard B. Lipton and Marcelo E. Bigal

Chapter 7: Concomitant Symptoms in Migraine, Arne May & Anne Stankewitz

III. Clinical Perspective

Chapter 8: Clinical Neuroimaging of Migraine, Randolph W. Evans

Chapter 9: Prophylaxis: What Measures?, Stephen Silberstein

Chapter 10: Iron Accumulation in Migraine, Inge H. Palm-Meinders, Michel D. Ferrari, Mark C. Kruit

Chapter 11 : Migraine and Brain Lesions, Inge H. Palm-Meinders, Michel D. Ferrari, Mark C. Kruit

Chapter 12: Clinical Utility of Objective Measures, Franz Riederer, Andreas R. Gantenbein & Peter S. Sándor

Chapter 13: Migraine Genes - Clinical and Preclinical Perspectives, Claudia M. Weller, Boukje de Vries, Gisela M Terwindt, Michel D. Ferrari, Joost Haan, and Arn M.J.M. van den Maagdenberg

IV. Imaging Migraine

Chapter 14: In Search of Future Treatments, Richard Hargreaves and David Dodick

Chapter 15: Imaging migraine: A history, Jes Olesen and Peer Tfelt-Hansen

Chapter 16: Focus on the Midbrain, Hans-Christoph Diener, Arne May

Chapter 17: Diffusion Weighted Imaging in Migraine, Christos Sidiropoulos and Panayiotis D. Mitsias

Chapter 18: DIFFUSION TENSOR IMAGING ABNORMALITIES IN MIGRAINE,
Maria A. Rocca and Massimo Filippi

Chapter 19: Morphometric changes and VBM, Arne May

Chapter 20: SURFACE-BASED STRUCTURAL CHANGES IN MIGRAINE, Cristina Granziera

Chapter 21: Changing receptors in Migraine state, Geneviève Demarquay and François Mauguière

Chapter 22: 15O PET studies in migraine, Marie Denuelle, Pierre Payoux, Nelly Fabre and Gilles Geraud

Chapter 23 : Imaging activation in the migraine state, Till Sprenger, Christian Seifert, Peter J. Goadsby

Chapter 24: Metabolites and migraine, Caterina Tonon, Giulia Pierangeli, Sabina Cevoli, Pietro Cortelli, Raffaele Lodi

Chapter 25: Visual aura, Nouchine Hadjikhani, Maurice B. Vincent

Chapter 26: Functional Imaging of the Migraine Brain: New Insights into Brain Dysfunction, Eric A. Moulton

Chapter 27: TMS and MEG studies in migraine, Sheena K Aurora, Sidra Saeed, and Susan M Bowyer

Chapter 28: Magnetic Resonance Angiography and Migraine, M. Sohail Asghar and Messoud Ashina

Chapter 29: Transcranial Magnetic Stimulation (TMS) / Repetitive Transcranial Magnetic Stimulation (rTMS), Magdalena Sarah Volz and Felipe Fregni

Chapter 30: Measures of cortical excitability, Gianluca Coppola and Jean Schoenen

Chapter 31: Drug Effects on Cortical Excitability, Susan M. Bowyer and Panayiotis D. Mitsias

V. Conclusions
Chapter 32: Defining the Migraine Phenotype, Todd J. Schwedt and David W. Dodick

Chapter 33: The Future of Imaging in Migraine Diagnosis and Treatment, David Borsook and Lino Becerra

Chapter 34: Can Imaging Effectively Transform Migraine Treatment?, David Borsook, Arne May, Peter Goadsby, Richard Hargreaves

About the Author

David Borsook, MD, PhD
Director, Pain & Analgesia Imaging Neuroscience (P.A.I.N.) Group
McLean Hospital, Masschussetts General Hospital, and Children's Hospital
Belmont, MA

Arne May, MD, PhD
Institut für Systemische Neurowissenschaften
Zentrum für Experimentelle Medizin
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany

Peter Goadsby, MD, PhD
Director, UCSF Headache Center
Department of Neurology
University of California, San Francisco
San Francisco, CA

Richard Hargreaves, PhD
Vice President
Worldwide Head of Basic Research
Neuroscience
Merck Research Laboratories
West Point PA

Reviews

"The Migraine Brain - Imaging Structure and Function reviews the astonishing progress that has been made, based on diverse noninvasive imagining technologies, in visualizing the neural basis of a disorder that, not long ago, was essentially invisible. While some features of migraine could be detected through the neurologic exam, the most salient symptoms, including the headache, were characterized largely through subjective report. Although this
multi-authored volume focuses on imaging, it provides a relatively broad outline of migraine, making it useful and interesting for readers beyond the specialist." -- Steven E. Hyman, MD, Broad Institute of Harvard
and MIT, Cambridge, MA
"It is a superb summary of the explosion of recent research into the origins and causes of migraine. It highlights the many ways in which the migraine brain is different both during and between individual attacks of headache. It is especially timely because until recently we have been dependent upon clinical observation and static imaging techniques for hints about the origins and process of migraine. Now genetic advances and functional imaging techniques, all
elegantly summarized by the world-class expert authors of this book, have put us on a fast track to solving the mysteries of migraine. I view this as essential reading for anyone looking for a
synthesis of the exciting progress being made in the dynamic field of migraine research." -- Elizabeth Loder, MD, MPH, The John R. Graham Headache Center, Chief, Division of Headache and Pain, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
"This book is unique in this field. Functional neuroimaging is cutting edge...This book
puts functional neuroimaging of the migraine into clinical context. It can and will be used by readers to learn about the migraine brain and the neuroimaging tools available to study it, to apply this knowledge to help patients, and to inspire further research in this field." -- Amaal Jilani Starling, MD, Mayo Clinic Arizona, Doody's
"The Migraine Brain is an expertly authored and edited compendium of insights into human migraine pathophysiology. The strength of the book is its informative synthesis of an enormous body of literature, accompanied by clinical interpretation by recognized experts in the field. The writing is accessible, and the topics are timely. The Migraine Brain is poised to be a standard reference on the topic of migraine pathophysiology and
neuroimaging." -- Jonathan H. Smith, MD, Neurology
"This book is a major contribution to the study of the migraine headache. ... The editors and the authors of the content in this important volume have provided a service of incalcuable value with the information they provide in this milestone work on the migraine brain. They are to be heartily congratulated for their work in researching and writing for this work, and generously sharing their knowledge, experience, and insight." --Biz India