Table of Contents
Contributors
Preface
SECTION I: Introduction to Basic Neuroscience
Eric J. Nestler
1. Overview of Brain Development
John L. R. Rubenstein
2. Neurochemical Systems in the Central Nervous System
Ariel Y. Deutch and Robert H. Roth
3. Principles of Electrophysiology
Evelyn K. Lambe
4. Principles of Signal Transduction
Jean-Antoine Girault and Paul Greengard
5. Synaptic and Neural Plasticity
Saïd Kourrich and Antonello Bonci
6. Principles of Molecular Biology
Steven E. Hyman and Eric J. Nestler
7. Epigenetics of Psychiatric Diseases
Bryan E. McGill and Huda Y. Zoghbi
SECTION II: New Methods and New Technologies for Preclinical and
Clinical Neurobiology
Karl Deisseroth
8. Transgenic Tools and Animal Models of Mental Illness
Lisa M. Monteggia, William Carlezon, Jr. and Ralph J. DiLeone
9. Application of Stem Cells to Understanding Psychiatric
Disorders
Kimberly M. Christian, Hongjun Song and Guo-li Ming
10. Optogenetic Technologies for Psychiatric Disease Research:
Current Status and Challenges
Lief E. Fenno and Karl Deisseroth
11. Blood-Brain Barrier Opening and Drug Delivery Using Focused
Ultrasound and Microbubbles
Elisa E. Konofagou
12. Genetic Methodologies and Applications
Shaun M. Purcell
13. The Brain and Its Epigenome
Amanda C. Mitchell, Yan Jiang, Cyril J. Peter, Ki A. Goosens and
Schahram Akbarian
14. Network Methods for Elucidating the Complexity of Common Human
Diseases
Eric E. Schadt
15. Brain Imaging Methodologies
Hanzhang Lu, Yihong Yang and Peiying Liu
16. Image-Guided Brain Stimulation
Mark S. George, John J. Taylor and Jaimie M. Henderson
SECTION III: Psychotic Disorders
Pamela Sklar
17. Diagnosis of the Psychoses
Lianne Morris Smith, Julie W. Messinger and Dolores Malaspina
18. Genetics of Schizophrenia and Bipolar Disorder
Pamela Sklar
19. Genomic Syndromes in Schizophrenia: Overlapping Phenotypes
George Kirov, Michael O'Donovan and Michael J. Owen
20. Neuroimaging of Psychotic Disorders
Stephan Heckers, Neil Woodward and Dost Öngür
21. Cognitive and Motivational Neuroscience of Psychotic
Disorders
Alan Anticevic, Erin C. Dowd and Deanna M. Barch
22. Mouse Models of Schizophrenia and Bipolar Disorder
Mikhail V. Pletnikov and Christopher A. Ross
23. Cortical GABA Neurons in Schizophrenia
Allison A. Curley and David A. Lewis
24. Synaptic Disease in Psychiatry
Seth G. N. Grant
25. Neurodevelopment and Schizophrenia
Ester J. Kwon, Takahiro Soda and Li-Huei Tsai
26. Psychosis Proneness
Raquel E. Gur
27. Psychotic Disorders: Neurochemistry and Pharmacotherapy
Carol A. Tamminga and Elena I. Ivleva
28. The Neurobiology of Bipolar Disorder
Katherine E. Burdick, Stephen J. Haggarty, and Roy Perlis
SECTION IV: Mood Disorders
Helen S. Mayberg
29. The Diagnosis of Mood Disorders
Jan Fawcett and Brant Hager
30. Genetics of Depression
Douglas F. Levinson
31. Animal Models of Mood Disorders
Georgia E. Hodes and Scott J. Russo
32. Molecular and Cellular Pathogenesis of Depression and
Mechanisms for Treatment Response
Ronald S. Duman
33. Pathogenesis of Depression: Clinical Studies
Maura A. Furey, Daniel C. Mathews and Carlos A. Zarate Jr.
34. Neural Circuitry of Depression
Joseph L. Price and Wayne C. Drevets
35. Neurobiology of Depression in Later Life: Anatomy of
Melancholia
K. Ranga Rama Krishnan
36. Gonadal Steroids and Mood Disorders
David R. Rubinow, Peter J. Schmidt and Claire D. Craft
37. Depression and Medical Illness
Tami D. Benton, Joshua Blume, Paul Crits-Christoph, Benoit Dube and
Dwight L. Evans
38. Treatments for Depression
Dan V. Iosifescu, James W. Murrough and Dennis S. Charney
SECTION V: Anxiety Disorders
Kerry J. Ressler
39. Diagnosis of Anxiety Disorders
Meghan E. Keough, Murray B. Stein and Peter P. Roy-Byrne
40. Genetics of Anxiety Disorders
Javier A. Perez, Takeshi Otowa, Roxann Roberson-Nay and John M.
Hettema
41. The Neurobiology of Fear and Anxiety: Contributions of Animal
Models to Current Understanding
Christopher K. Cain, Gregory M. Sullivan and Joseph E. LeDoux
42. Differential roles of GABA Receptors in Anxiety
Hanns Möhler
43. Prefrontal Cortex Regulation of Emotion and Anxiety
Bronwyn M. Graham and Mohammed R. Milad
44. Developmental Components of Fear and Anxiety in Animal
Models
Siobhan S. Pattwell, Anne-Marie Mouly, Regina M. Sullivan and
Francis S. Lee
45. Functional Neurocircuitry and Neuroimaging Studies of Anxiety
Disorders
Madeleine S. Goodkind, Anett Gyurak and Amit Etkin
46. Novel Treatment Approaches for Anxiety Disorders
Anita Van Zwieten, Gail A. Alvares and Adam J. Guastella
47. Pharmacotherapy of Anxiety Disorders
James W. Murrough, Dan V. Iosifescu, and Dennis S. Charney
48. Neurobiology and Treatment of OCD
Susanne E. Ahmari and H. Blair Simpson
49. Neurobiology and Treatment of PTSD
Karen E. Murray, Orion P. Keifer, Jr., Kerry J. Ressler, Seth Davin
Norrholm and Tanja Jovanovic
SECTION VI: Substance Use Disorders
Antonello Bonci and Nora D. Volkow
50. Animal Models of Addiction
Rafael Maldonado, J. David Jentsch, Brigitte L. Kieffer, and
Christopher J. Evans
51. Cellular and Molecular Mechanisms of Addiction
Kathryn J. Reissner and Peter W. Kalivas
52. The Genetic Basis of Addictive Disorders
David Goldman
53. Brain Development and the Risk for Substance Abuse
Kristina Caudle and BJ Casey
54. Molecular Imaging in Addictive Disorders
Chelsea L. Robertson, Steven M. Berman and Edythe D. London
55. Brain, Reward, and Drug Addiction
Vani Pariyadath, Martin P. Paulus and Elliot A. Stein
56. Magnetic Resonance Spectroscopy Studies in Substance
Abusers
Linda Chang, Christine C. Cloak and John L. Holt
57. Pharmacotherapy of Substance Use Disorders
Jane B. Acri and Phil Skolnick
58. Epidemiology of Substance Use Disorders
Denise B. Kandel, Mei-Chen Hu and Pamela C. Griesler
SECTION VII: Dementia
David M. Holtzman
59. Clinical and Neuropsychological Features of Alzheimer's
Disease
Jason Hassenstab, Jeffrey Burns and John C. Morris
60. The Genetics of Alzheimer's Disease
Rudolph E. Tanzi
61. Experimental Animal Models of Alzheimer's Disease
Dave Morgan
62. Structural, Functional and Molecular Neuroimaging Biomarkers
for Alzheimer's Disease
James B. Brewer, Jorge Sepulcre and Keith A. Johnson
63. Fluid Biomarkers for Alzheimer's Disease
Anne M. Fagan
64. Current Therapies for Alzheimer's Disease
Mary Sano and Judith A. Neugroschl
65. Disease-Modifying Therapies for Alzheimer's Disease
Joshua D. Grill and Jeffrey Cummings
66. Lewy Body Dementias
Stella Karantzoulis and James E. Galvin
67. Clinical Features and Pathogenesis of FTD
Georges Naasan and Bruce Miller
68. Pathogenesis, Diagnosis and Treatment of Vascular and Mixed
Dementias
Helena Chang Chui
69. Clinical Features and Pathogenesis of Prion Disease
Joel C. Watts and Michael D. Geschwind
SECTION VIII: Psychiatric Disorders of Childhood Onset
Joseph D. Buxbaum
70. Epidemiology of Neuropsychiatric and Developmental Disorders of
Childhood
Elise B. Robinson, Benjamin M. Neale and Mark J. Daly
71. Rare Variants of Substantial Effect in Psychiatric Disorders of
Childhood Onset
Heather C. Mefford
72. Epigenetics in Early Life Programming
Tracy L. Bale
73. Animal Models in Psychiatric Disorders of Childhood Onset
Richard Paylor, Alexia M. Thomas, Surabi Veeraragavan and Shannon
M. Hamilton
74. Neuropathology and Synaptic Alterations in Neurodevelopmental
Disorders
Mara Dierssen and Salvador Martínez
75. Functional Connectivity: Application to Developmental
Disorders
Luke Bloy, Ragini Verma and Timothy P.L. Roberts
76. Intellectual Disability Syndromes
Charles E. Schwartz, Fiorella Gurrieri and Giovanni Neri
77. Autism Spectrum Disorders
Alexander Kolevzon, A. Ting Wang, David Grodberg and Joseph D.
Buxbaum
78. Neurobiology of Attention Deficit Hyperactivity Disorder
Stephen V. Faraone and Joseph Biederman
79. Tourette Syndrome and Tic Disorders
Kyle Williams, Michael H. Bloch, Matthew W. State and Christopher
Pittenger
80. Novel Therapeutics in Childhood Onset Psychiatric Disorders
Dorothy E. Grice, Alexander Kolevzon, Walter E. Kaufmann and Joseph
D. Buxbaum
SECTION IX: Special Topic Areas
Dennis S. Charney
81. DSM-5 Overview and Goals
David J. Kupfer and Susan K. Schultz
82. The Infirmities of Psychiatric Diagnosis
Steven E. Hyman
83. Toward Precision Medicine in Psychiatry: The NIMH Research
Domain Criteria Project
Bruce N. Cuthbert and Thomas R. Insel
84. The Neurobiology of Personality Disorders: The Shift to
DSM-5
M. Mercedes Perez-Rodriguez, Antonia S. New and Larry J. Siever
85. The Neurobiology of Aggression
R. James R. Blair
86. Neurobiology of Social Attachment
Adam S. Smith, Kelly Lei and Zuoxin Wang
87. The Neurobiology of Sleep
Giulio Tononi and Chiara Cirelli
88. The Neurobiology of Resilience
Adriana Feder, Margaret Haglund, Gang Wu, Steven M. Southwick and
Dennis S. Charney
89. The Neurobiology of Eating Disorders
Thomas B. Hildebrandt and Amanda Downey
Index
Dennis S. Charney, MD is Dean at the Icahn School of Medicine at
Mount Sinai, Executive Vice President for Academic Affairs, The
Mount Sinai Medical Center, and Anne and Joel Ehrenkranz Professor
in the Departments of Psychiatry, Neuroscience, and Pharmacology &
Systems Therapeutics at the Icahn School of Medicine at Mount Sinai
in New York, NY. He is a world expert in the neurobiology and
treatment of mood and anxiety disorders. He has made
fundamental
contributions to the understanding of neural circuits and
neurochemistry related to human anxiety, fear, mood and discovery
of new treatment for mood and anxiety disorders. He later expanded
this area into
pioneering research related to the psychobiological mechanisms of
human resilience to stress. His work has been carried out over two
decades at Yale University School of Medicine, and during four
years at the National Institute of Mental Health (NIMH). It
continues today at the Icahn School of Medicine at Mount Sinai.
Joseph D. Buxbaum, PhD, is a Professor of Psychiatry, Neuroscience,
and Genetics and Genomic Sciences at the Icahn School of Medicine
at Mount Sinai, where he is also director of the Seaver Autism
Center for Research and Treatment. He is a world-renowned molecular
geneticist and spearheads research into human psychiatric and
neurological diseases. As Vice Chair for Research in Psychiatry,
Dr. Buxbaum helps set the research direction for the Department,
which is ranked among the top 20
psychiatry departments in the country in NIH funding.
Pamela Sklar, MD, received her BA from St. John's College and her
MD and PhD from Johns Hopkins School of Medicine and Neuroscience.
She is a neuroscientist, human geneticist and clinical psychiatrist
investigating the genetic causes of psychiatric disorders,
including schizophrenia and bipolar disorder. A major focus of her
prior work has been to identify susceptibility genes for
psychiatric diseases by applying tools developed for understanding
and characterizing human sequence variation.
Currently, she is Chief of the Division of Psychiatric Genomics,
and Professor of Psychiatry, Neuroscience, Genetics and Genomic
Sciences.
Eric J. Nestler, MD, PhD, received his BA, MD, and PhD degrees from
Yale University. He then served on the Yale faculty, where he was
named the Elizabeth Mears and House Jameson Professor of Psychiatry
of Neurobiology and Director of the Abraham Ribicoff Research
Facilities. In 2000, Dr. Nestler was named the McGinley Professor
of Psychiatry and Chairman of the Department of Psychiatry at the
University of Texas Southwestern Medical Center at Dallas, before
accepting his current position at
Mount Sinai in 2008. Dr. Nestler has been a pioneer in the field of
molecular psychiatry, whose research has helped us understand the
molecular mechanisms of addiction and depression based on work
in
animal models.
"As psychiatric diagnoses continue to be hotly debated, the Fourth
Edition of this mainstay volume reminds the field of our deeper
understanding of the neurobiological underpinnings of the brain,
just a decade after the first Edition was published. This
completely revamped Edition highlights articles by leaders in the
fields of psychiatry and neuroscience and offers intelligent
insights into how neuroscience may impact how we will diagnose and
treat individuals
suffering from mental illness in the very near future. The book
continues to be a tour de force."
-- Dilip V. Jeste, M.D., Estelle and Edgar Levi Chair in Aging,
Director, Sam and Rose Stein Institute for Research on Aging,
Distinguished Professor of Psychiatry & Neurosciences
University of California, San Diego
President, American Psychiatric Association, 2012
"The editors have compiled an outstanding and comprehensive
overview of the biological basis of mental illness including
detailed descriptions of state-of-the-art molecular, cellular, and
circuit methodologies in animals and people that will lead the
field to improved diagnostic tests and treatments for these
debilitating conditions. This book is an important resource for
those interested in entering the field as well as for accomplished
researchers and
practitioners."
-- Arvid Carlsson, MD, PhD, Nobel Laureate in Physiology or
Medicine, 2000
"This book continues to be an outstanding testament to the effort
made towards fundamental understanding of psychiatric disorders.
The fourth edition is an excellent and complete update on the
biological basis of psychiatric disorders. Every psychiatrist
should read and refer this book." -- Doody's
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