Table of Contents

Introduction: An Overview of the Shock Problem.- Session I: Shock and the Cardiovascular System.- Introductory Remarks.- Proposed Reclassification of Shock States with Special Reference to Distributive Effects.- Discussion.- Participation of Endogenous Vasoactive Agents in the Pathogenesis of Endotoxin Shock.- Discussion.- Pulmonary Dysfunction in Shock.- Discussion.- The Lung Lesion in Shock.- Physiologic Mechanisms in Clinical Shock.- Role of Leukocytes in the Lung After Endotoxin Administration.- Fate of Endotoxin in the Circulation.- Discussion.- Splanchnic Blood Flow in Experimental Shock.- Discussion.- Are Adrenergic Overactivity and Splanchnic Vasoconstriction the Prime Pathophysiological Events in Shock?.- Effects of Endotoxin on the Vascular Architecture of Intestinal Mucosa.- Role of Vasopressin and Angiotensin in Response of Splanchnic Resistance Vessels to Hemorrhage.- Platelet, Hemodynamic, and Respiratory Changes in Shock, Sepsis, and Trauma.- Discussion.- Session II: Shock and Metabolism.- Introductory Remarks.- Immunochemical and Physiologic Insulin Lack During Lethal E. coli Septicemia in the Subhuman Primate.- What Mechanisms Influence Oxygen Transport and Oxygen Tissue Delivery in Endotoxic and Hemorrhagic Shock?.- Oxyhemoglobin Dissociation Curve in Hemorrhagic and Septic Shock.- Effects of Endotoxin and E. coli Shock on the Metabolism of Lipids and Carbohydrate.- The Mechanism of the "Lung Lesion" in Shock.- Irreversibility in the Post-Transfusion Phase of Hemorrhagic Shock.- Histamine Release in Endotoxin Shock: Effect of Dexamethasone Administration.- Dopamine in the Treatment of Shock.- Liver Metabolism and Energy Production in Staphylococcus aureus Septic Shock in Mice.- Myocardial Metabolism During Acute Hemorrhagic or Endotoxic Shock.- Metabolic Changes in Hemorrhagic Shock.- General Discussion.- Session III: Toxic Factors in Shock.- Introductory Remarks.- Release of Toxic Agents in Septic Shock.- The Relationship Between Oxygen Uptake and a Toxic Factor in Septic Shock.- Discussion.- Role of the Pancreas in the Pathogenesis of Circulatory Shock.- Vascular Lesions in Endotoxemia.- The Role of Targets and Mediators in Endotoxin Shock.- Discussion.- Liberation of Vasoactive Materials from Mast Cells in Anaphylactic Shock.- Proteases and Antiproteases in Experimental Low-Flow States.- Prolylcarboxypeptidase in Biological Fluids.- Discussion.- Does Endotoxin Have Direct or Indirect Effects on the Heart?.- Pulmonary Dysfunction After Shock and Trauma.- Discussion.- Biochemical-Biophysical Basis of Shock.- Afterword.- Participants and Special Guests.- General Subject Index.