Table of Contents

Section 1: Nuclear medicine in tumor diagnosis and therapy

Part A: Diagnosis

1. Tumor-seeking radiopharmaceuticals: nature and mechanisms

2 Radionuclide imaging of hepatic tumors

3 PET in lymphoma and malignant melanoma

4 Parathyroid imaging

5 Adrenocortical scintigraphy

6 Gallium scintigraphy in tumor diagnosis and management

7 Thallium-201 chloride: a tumor imaging agent

8 MIBG in the diagnosis of neuroendocrine tumors

9 Peptide receptor scintigraphy in oncology

10 The diagnostic role of radiolabeled antibodies in cancer

11 Cancer cell biology basis for nuclear oncology

12 Differentiated thyroid carcinoma

13 Medullary thyroid cancer

14 Breast scintigraphy

15 Pediatric tumors

16 Functional analysis of cancer therapy effects in other organs

17 The use of intraoperative probes in surgical oncology

18 The sentinel lymph node in surgical oncology

19 FDG PET Imaging of Head and Neck Cancer

20 External Beam Radiotherapy Treatment Planning with PET

21 PET in aerodigestive tumors

22 PET in gynecological tumors (breast, cervical and ovarian)

23 Nuclear medicine imaging in pediatric oncology

24 Positron Emission Tomography (PET) in genitourinary tumors: prostate, bladder, testicular and renal cancer

25 Future clinical applications of PET (amino acid and nucleoside imaging)

26 PET imaging of brain tumors


Section 1: Nuclear medicine in tumor diagnosis and therapy

Part B: Radionuclide therapy

27 Principles of radionuclide therapy

28 Dosimetric and radiobiological considerations: The MIRD concept

29 Dosimetric and radiobiological considerations: Patient-individual dosimetry

30 Radioiodine therapy of the thyroid: Treatment of benign thyroid diseases

31 Radioiodine therapy of the thyroid: Treatment of thyroid malignancies

32 Phosphorus-32 therapy in myeloproliferative disorders

33 Palliation of bone pain

34 Radioimmunotherapy of hematologic neoplasms

35 Radioimmunotherapy of solid tumors

36 MIBG therapy

37 Receptor-targeted radiopeptide therapy

38 Use of radiolipiodol in the treatment of hepatic tumours

39 Alternative approaches to targeting therapy

40 New developments: Nuclear gene therapy

41 Atlas 1: PET and PET/CT

42 Atlas 2: SPET and SPET/CT


Section 2: Nuclear medicine in disorders of bones and joints

43 Bone scintigraphy: the procedure and interpretation

44 Evaluation of primary bone tumors

45 The evaluation of malignancy: metastatic bone disease

46 Assessment of infection

47 Radionuclide assessment of the painful joint prosthesis

48 Vascular manifestations

49 Bone scintigraphy in trauma

50 Bone scintigraphy in sports medicine

51 Growth and metabolic disorders

52 Arthritis: current status of scintigraphy and future trends

53 Radiation synovectomy


Section 3: Quantitative studies of gastrointestinal function

54 Salivary gland disorders

55 Esophageal function (transport and motility)

56 Gastric motility

57 Intestines: evaluation of absorption

58 Studies of small bowel and colonic transit

59 Hepatobiliary function: biliary kinetics

60 Scintigraphic measurement of hepatic function


Section 4: Nuclear medicine in acute care

61 Nuclear cardiology and cardiac transplantation

62 Cardiovascular conditions: venous thrombosis

63 Pulmonary embolism

64 Non-embolic disease of the lungs

65 Gastrointestinal bleeding

66 Cholescintigraphy

67 Neonatal hyperbilirubinemia

68 Nuclear medicine in acute care of neurological patients

69 Radiolabeled agents for the localization of infection and inflammation

70 Undiagnosed fever

71 Inflammatory bowel disease

72 Nuclear imaging in cardiovascular infection and cardiac transplant rejection

73 The immunocompromised patient


Section 5: Nuclear cardiology

74 Radiopharmaceuticals for the study of the heart

75 Radionuclide ventriculography and the assessment of impaired ventricular function

76 Infarct avid imaging and myocardial perfusion scintigraphy techniques using single photon radiotracers

77 Cardiac positron emission tomography

78 Cardiac stress

79 The detection of coronary artery disease

80 Assessment of prognosis in patients with known or suspected coronary artery disease

81 Assessment after myocardial revascularization

82 Assessment of myocardial viability in dysfunctional myocardium

83 Myocardial infarction: the assessment of thrombolysis

84 Congenital heart disease

85 Single-photon imaging of myocardial metabolism: the role of iodine 123 fatty acids and fluorine-18 deoxyglucose

86 Clinical applications of PET

87 Myocardial innervation: imaging and quantification

88 Nuclear medicine techniques in the assessment of human thrombosis and atheroma


Section 6: Nuclear medicine in neurological and psychiatric diagnosis

89 The blood-brain barrier

90 Lipophilic tracers: the amines

91 Lipophilic tracers for the study of regional cerebral blood flow

92 Ligands for neuroreceptor imaging by positron or single photon emission tomography

93 PET tracers for brain scanning

94 Neuroactivation

95 Image analysis in brain SPECT and PET

96 SPECT brain imaging in cerebrovascular disease

97 Nuclear medicine in the management of a patient with epilepsy

98 Nuclear medicine and the management of patients with Parkinson's movement disorders

99 Anxiety disorders and affective disorders

100 Addictions

101 The management of patients with schizophrenia

102 PET and SPECT imaging in evaluating Alzheimer's disease and related dementias

103 Nuclear medicine and drug studies in the brain

104 Cerebrospinal fluid physiology, clearance flow studies and cerebrospinal fluid shunt studies

105 Atlas 3: PET brain atlas


Section 7: Nuclear medicine in renal disorders

106 Overview of renal nuclear medicine

107 Radiopharmaceuticals: their intrarenal handling and localization

108 Dynamic static renal imaging

109 Quantitative evaluation of clearance

110 Measurement and interpretation of renal transit times

111 The role of PET in renal nuclear medicine

112 Renal infection

113 Pediatric aspects of radionuclides in nephrourology

114 Nuclear medicine in the clinical diagnosis and treatment of obstructive uropathy

115 Vascular disorders, with emphasis on hypertension

116 Renal failure

117 Space-occupying lesions and trauma

118 Renal transplant evaluation

119 The genital tract


Sction 8: Basic sciences

120 Fundamental molecular/cell biology

121 Radioisotope production

122 Radiochemistry

123 Radiopharmacy

124 Basic physics and detection of radiation

125 Nuclear medicine imaging instrumentation

126 Nuclear medicine computers: Basic principles

127 Nuclear medicine computers: Applications

128 Single photon emission computed tomography (SPECT)

129 Positron emission tomography (PET)

130 Primer on molecular imaging

131 Radiation protection and dosimetry in clinical practice

132 Clinical decision making: an introductory, quantitative approach to diagnostic investigations

133 ecision analysis fundamentals

Reviews

"The new third edition of this textbook is unquestionably the ultimate reference book of this evolving specialty...I recommend 'Nuclear Medicine in Clinical Diagnosis & Treatment' as the definitive reference for the practice of clinical nuclear medicine." JAMA March 2005 p.1267