Table of Contents

Section A The Molecular Basis of Cell and Tissue Organization; Cell and Tissue Organisation - Potten et al; Regulation of the Cell Cycle - Pardee; Overview of Oncogenesis - Parsons et al; Inherited Predispositions to Cancer - Evans; Human DNA Tumour Viruses - Griffin et al; RNA Viruses - Yoshida; Genetic Instability and DNA Repair - Kohn et al; Telomerase - Shay et al; Apoptosis - Reed; Signalling by Steroid Receptors - Fuqua et al; Signalling by Cytokines - Farrar et al; Signalling by Tyrosine Kinases - Carraway et al; Signalling by TGF Beta - Derynck et al; Wnt Signal Transduction - Miller; Extracellular Matrix: The Networking Solution - Bissell et al; Invasion and Metastasis - Liotta et al; Angiogenesis - Modlich et al; Cell Proliferation in Carcinogenesis - Wright; Section B The Causation and Prevention of Cancer; Identifying Cancer Causes through Epidemiology - Adami et al; Mechanisms of Chemica l Carcinogenesis - Gooderham et al; The Formation of DNA Adduct - Phillips; Physical Causes of Cancer - Schwartz; Non-Genotoxic Causes of Cancer - Jirtle et al; Infectious Agents and Cancer - Newton; Short-term Testing for Genotoxicity - Gatehouse; Cancer Bioassays for Pharmaceuticals: A Regulatory Perspective - Degeorge et al; Molecular Epidemiology of Cancer - Vineis; Dietary Genotoxins and Cancer - Sugimura et al; Tobacco Use and Cancer - Hecht; Occupational Causes of Cancer - Vainio et al; Anti-Genotoxins and Cancer - Peters et al; Intervention and Chemoprevention of Cancer - Kellof et al; Section C Diagnostic Imaging and Image-Guided Intervention; Plain Film Radiography - Silas et al; Computed Tomography - Rosenfield; Ultrasound - Hann; Magnetic Resonance Imagery - Saini et al; Nuclear Medicine - Lewis et al; Mammography - Levin; Percutaneous Biopsy - Mueller et al; Transcatheter Therapy - Bettmann; Direct Percutaneous Tumour Therapy - Casciani et al; Section D Systemic Oncology; Introduction to the Diagnosis of Cancer - Wilczynski; Skin - Murphy et al; Oral Cavity and Major and Minor Salivary Glands - Auclair et al; Respiratory Tract - Hasleton; Upper Gatrointestinal Tract - Fenoglio-Preiser et al; Lower Gastrointestinal Tract - Jass; Liver, Gall Bladder and Extrahepatic Bile Ducts - Anthony; Pancreas - Hruban et al; Endocrine Organs - Asa et al; Breast - Masood et al; Female Reproductive System - Nuovo et al; Urinary Tract - Amin et al; Male Genital Tract - Ulbright; Lymph Nodes - Mueller-Hermelink et al; Bones and Joints - Weiss; Soft Tissues - Nascimento et al; Pleura and Peritoneum - Fletcher et al; Heart - Virmani et al; Neuromuscular System - Fung et al; Eye and Ocular Adnexa - Jain et al ; Ear - Wenig; Section E Pre-clinical Models for Human Cancer; Advantages and Limitations of Models for Human Cancer - Nicolson et al; Basic Tissue Culture in Cancer Research - Cavanaugh; Transgenic Technology in the Study of Oncogenes and Tumour Suppressor Genes - Wynshaw-Boris; Gene Knockouts in Cancer Research - Pandolfi et al; Human Tumours in Animal Hosts - Clarke; Mammary Tumour Induction in Animals as a Model for Human Cancer - Russo et al; Mathematical Models in Cancer Research - Chaplain; Models for Tumour Growth and Differentiation - Riedel; Angiogenesis Models - Kohn et al; Models for Tumour Cell Adhesion and Invasion - Haier et al; Tumour Metastatis Models - Hill et al; Models for Tumour Cell-endothelial Cell Interactions - Haier et al; Modelling Tumour Tissue Interactions - Miller; Models for Drug-development and Drug-resistance - Chou et al; Models for Immunotherapy and Cancer Vaccines - Schirrmacher et al; Gene Therapy Models - Gerson et al; Models for Carcinomas - Eccles; Haematological Malignancies in Cancer Research - Haier et al; Models for Melanomas and Sarcomas - Bar-Eli et al; Models for CNS Malignancies - Bigner et al; Models for Endocrine Cancer - Newbold; Section F The Treatment of Human Cancer; Mechanisms of Action of Cancer Chemotherapeutic Agents - Grem et al; Drug Resistance and Reversal - Harbottle; Molecular Mechanisms of Radiotherapy - Milas et al; Antibodies and Recombinant Cytokines - Sznoi et al; Genetic and Cellular Vaccines - Carbone et al; Differentiation Therapy - Lotan; Chemoprevention - Hawk et al; Aitnsense and Ribozyme Therapy - Scanlon et al; Hormonal Therapy - Craig et al; Antiangiogenic Therapy - Turner et al; Targeting the Extracellular Matrix - Giavazzi et al; Growth Factor Receptor Blockade - Radinsky; Signal Transduction Pathway Targeting - Workman; DNA Repair and the Cell Cycle as Targets for Therapy - Rajewsky et al; Gene Therapy - Tumour Suppressor Replacement/oncogene Suppression - Roth et al; GPAT - Lemoine et al; Stem Cell Transplantation - Nagler; Novel Surgical Strategies in the Management of Cancer - Darzi et al; Translational Research - Overview of Phases I, II and II Clinical Trials - Weiner et al