Table of Contents

History and Background 1. Discovery of Aspartame 2. Sweeteners: An Overall Perspective Metabolism 3. Absorption of Peptides, Amino Acids, and Their Methylated Derivatives 4. Aspartate and Glutamate Metabolism 5. Phenylalanine Metabolism 6. Methanol Metabolism and Toxicity 7. Aspartame Metabolism in Animals 8. Tissue Distribution of Orally Administered Isotopically Labeled Aspartame in the Rat Sensory and Dietary Aspects 9. Projected Aspartame Intake: Daily Ingestion of Aspartic Acid, Phenylalanine, and Methanol 10. Comparisons of Taste Properties of Aspartame with Other Sweeteners 11. Aspartame: Implications for the Food Scientist 12. Role of Sugar and Other Sweeteners in Dental Caries 13. Efficacy of Low-Calorie Sweeteners in Reducing Food Intake: Studies with Aspartame Preclinical Studies 14. Preclinical Studies of Aspartame in Nonprimate Animals 15. Chronic Feeding Studies with Aspartame and Its Diketopiperazine 16. Artificial Sweeteners and Bladder Cancer: Assessment of Potential Urinary Bladder Carcinogenicity of Aspartame and Its Diketo-piperazine Derivative in Mice 17. Aspartate-Induced Neurotoxicity in Infant Mice 18. Neuropathology Studies following Aspartame Ingestion by Infant Nonhuman Primates 19. Behavioral Testing in Rodents given Food Additives 20. Developmental Assessment of Infant Macaques Receiving Dietary Aspartame or Phenylalanine 21. Effect of Aspartame on the Learning Test Performance of Young Stumptail Macaques 22. Aspartame and Brain Tumors: Pathology Issues 23. Aspartame and Brain Tumors: Statistical Issues 24. Possible Neurohormonal Effects of Aspartame Ingestion Studies of Aspartame Metabolism in Humans 25. Chronic Ingestion of Aspartame in Humans 26. Aspartame Metabolism in Humans: Acute Dosing Studies 27. Aspartame Ingestion during Pregnancy 28. Aspartame Ingestion during Lactation 29. Aspartame Ingestion by Human Infants 30. Aspartame Ingestion by Phenylketonuric Heterozygous and Homozygous Individuals 31. Interactions of Aspartame and Glutamate Metabolism 32. Aspartame Use by Persons with Diabetes 33. Effects of Acute Aspartame Ingestion on Large Neutral Amino Acids and Monoamines in Rat Brain