Introduction. Synthesis, enzyme localization, and regulation of neurosteroids. Subunit specificity of steroid modulation of GABAA receptors. THDOC and the GABAA receptor. Neurosteoid modulation of delta subunit-containing GABA-A receptor channels. Potentiation and inhibition of GABAA receptor function by neuroactive steroids. Anabolic androgenic steroids and the brain: Novel actions at the GABAA receptor and on GABA-A receptor mediated behaviors. Withdrawal effects of a neuroactive steroid as a model of PMS: Synaptic physiology to behavior. GABA, estrogen, and sex differences in the brain. FGIN-1-X--A series of novel specific and efficacious ligands for the peripheral benzodiazepine receptor. GABAergic neuroactive steroids modulate selective ethanol actions: Mechanisms and significance. Allopregnanolone modulates the action of ethanol and stress on the activity of mesocortical dopaminergic neurons and HPA axis. 3a, 5a-THP's actions in the ventral tegmental area for lordosis: A model system for defining mechanisms and function of progestins. Premenstrual dysphoric disorder. Role of neurosteroids in epilepsy. Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids. Direct modulation of amino acid receptors by neuroactive steroids: Physiological and pharmacological Implications. On the neurosteroid mechanisms of action and their clinical potentials.
Smith, Sheryl S.
“The overwhelming amount of information in the field is well
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