Table of Contents

1. Epigenetics: From Phenomenon to Field D.E. Gottschling 2. A Brief History of Epigenetics G. Felsenfeld 3. Overview and Concepts C.D. Allis, T. Jenuwein, and D. Reinberg 4. Epigenetics in Saccharomyces cerevisiae M. Grunstein and S. Gasser 5. Position Effect Variegation, Heterochro-matin Formation, and Gene Silencing in Drosophila S.C.R. Elgin and G. Reuter 6. Fungal Models for Epigenetic Research: Schizosaccharomyces pombe and Neurospora crassa R.C. Allshire and E.U. Selker 7. Epigenetics of Ciliates E. Meyer and D.L. Chalker 8. RNAi and Heterochromatin Assembly R. Martienssen and D. Moazed 9. Epigenetic Regulation in Plants M. Matzke and O. Mittelsten Scheid 10. Chromatin Modifications and Their Mechanism of Action T. Kouzarides and S.L. Berger 11. Transcriptional Silencing by Polycomb Group Proteins U. Grossniklaus and R. Paro 12. Transcriptional Regulation by Trithorax Group Proteins R.E. Kingston and J.W. Tamkun 13. Histone Variants and Epigenetics S. Henikoff and M.M. Smith 14. Epigenetic Regulation of Chromosome Inheritance G.H. Karpen and R.S. Hawley 15. Epigenetic Regulation of the X Chromosomes in C. elegans S. Strome and W.G. Kelly 16. Dosage Compensation in Drosophila J.C. Lucchesi and M.I. Kuroda 17. Dosage Compensation in Mammals N. Brockdorff and B.M. Turner 18. DNA Methylation in Mammals E. Li and A. Bird 19. Genomic Imprinting in Mammals D.P. Barlow and M.S. Bartolomei 20. Germ Line and Pluripotent Stem Cells M.A. Surani and W. Reik 21. Epigenetic Control of Lymphopoiesis M. Busslinger and A. Tarakhovsky 22. Nuclear Transplantation and the Reprogramming of the Genome R. Jaenisch and J. Gurdon 23. Epigenetics and Human Disease H.Y. Zoghbi and A.L. Beaudet 24. Epigenetic Determinants of Cancer S.B. Baylin and P.A. Jones Appendices Index

Reviews

"The historical accounts of the rise of epigenetics as a field of study, combined with the inclusion of cutting-edging epigenetics research in various biological processes and model organisms, provide the reader with a clear sense of what epigenetics research is about, where it came from, where it is now, and where it is headed. It will prove to be the book that everyone with an interest in epigenetics would want to have and read." --Cell