Table of Contents

1. The Human Mitochondrion and Pathophysiology of Aging and Age-related Diseases D.C. Wallace 2. Sirtuins: A Universal Link between NAD, Metabolism, and Aging S.-i. Imai and L. P. Guarente 3. Calorie Restriction in Lower Organisms S.L. Helfand, J.H. Bauer, and J.G. Wood 4. Evolutionary Theory in Aging Research S.N. Austad and T.B.L. Kirkwood 5. An Overview of the Biology of Aging: A Human Perspective G.M. Martin and C.E. Finch 6. p53, Cancer, and Longevity L.A. Donehower and A.J. Levine 7. Aging Processes in Caenorhabditis elegans H.A. Tissenbaum and T.E. Johnson 8. Cellular Senescence: A Link between Tumor Suppression and Organismal Aging? J.M. Sedivy, U.M. Munoz-Najar, J.C. Jeyapalan, and J. Campisi 9. Genome-wide Views of Aging Gene Networks S.K. Kim 10. Aging in Mammalian Stem Cells and Other Self-renewing Compartments D.J. Rossi and N.E. Sharpless 11. Yeast, A Feast: The Fruit Fly Drosophila as a Model Organism for Research into Aging L. Partridge and J. Tower 12. DNA Repair and Aging V.A. Bohr, D.M. Wilson, III, N.C. de Souza-Pinto, I. van der Pluijm, and J.H. Hoeijmakers 13. Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis J.J. Kopchick, A. Bartke, and D.E. Berryman 14. Alzheimer's Disease: Genetics, Pathogenesis, Models, and Experimental Therapeutics P.C. Wong, D.L. Price, L. Bertram, and R.E. Tanzi 15. How Does Calorie Restriction Increase the Longevity of Mammals? R. Weindruch, R.J. Colman, V. P e9;rez, and A.G. Richardson 16. Determination of Aging Rate by Coordinated Resistance to Multiple Forms of Stress G.J. Lithgow and R.A. Miller 17. Molecular Mechanisms of Aging: Insights from Budding Yeast S.-J. Lin and D. Sinclair 18. Genetics of Exceptional Longevity T.T. Perls and P. Sebastiani 19. Mammalian Metabolism in Aging P. Puigserver and C.R. Kahn 20. Telomeres and Telomerase in Aging and Cancer J.W. Shay and W.E. Wright Index

Reviews

This excellent book provides an overview of the state of the field. Many of the people who contributed to the transformation of the biology of aging came together to review this topic...This results in a very complete book on the biology of aging that should serve as an excellent resource for both researchers and students. The Quarterly Review of Biology