Table of Contents

PREFACE xi ACKNOWLEDGMENT xvi ABOUT THE EDITOR xvii CONTRIBUTORS xix LIST OF TABLES AND FIGURES xxiii 1 PERSISTENT ORGANIC POLLUTANTS: AN OVERVIEW 1 Daniele Wikoff, Lauren Fitzgerald, and Linda Birnbaum 2 TOXICITY EQUIVALENCE FACTORS FOR DIOXIN AND RELATED COMPOUNDS 37 Michael DeVito 3 HISTORIC AND NEWER PERSISTENT ORGANIC POLLUTANTS IN FOOD 53 Janice Huwe 4 FLAME RETARDANTS: POLYBROMINATED DIPHENYL ETHERS AND THEIR REPLACEMENTS 89 Thomas F. Webster and Heather M. Stapleton 5 PHARMACOKINETICS OF 2,3,7,8-TETRACHLORODIBENZO-AND RELATED COMPOUNDS P-DIOXIN 109 James R. Olson 6 IMMUNOMODULATION BY PERSISTENT ORGANIC POLLUTANTS 171 Robert W. Luebke, Jamie C. DeWitt, Dori R. Germolec, Keith D. Salazar, and Nancy I. Kerkvliet 7 DEVELOPMENTAL NEUROTOXICITY OF DIOXINS 193 G. Jean Harry and Pamela J. Lein 8 EPIDEMIOLOGICAL EVIDENCE ON THE HEALTH EFFECTS OF PERFLUOROOCTANOIC ACID 229 Kyle Steenland, Tony Fletcher, and David A. Savitz 9 POLYBROMINATED P-DIOXINS AND DIBENZO-DIBENZOFURANS 255 Kurunthachalam Kannan, Chunyang Liao, and Hyo-Bang Moon 10 EPIDEMIOLOGICAL STUDIES ON CANCER AND EXPOSURE TO DIOXINS AND RELATED COMPOUNDS 303 Lennart Hardell and Mikael Eriksson 11 REPRODUCTIVE AND DEVELOPMENTAL EPIDEMIOLOGY OF DIOXINS 359 Anne Sweeney, Deborah J. del Junco, Marcella Warner, and Brenda Eskenazi 12 BISPHENOL A 381 Thaddeus T. Schug, Sarah A. Vogel, Laura N. Vandenberg, Joe M. Braun, Russ Hauser, Julia A. Taylor, Frederick S. vom Saal, and Jerold J. Heindel 13 PHTHALATES: HUMAN EXPOSURE AND RELATED HEALTH EFFECTS 415 John D. Meeker and Kelly K. Ferguson 14 THE SEVESO ACCIDENT 445 Angela Cecilia Pesatori and Pier Alberto Bertazzi 15 AGENT ORANGE: HEALTH AND ENVIRONMENTAL ISSUES IN VIETNAM, CAMBODIA, AND LAOS 469 Susan Hammond and Arnold Schecter 16 THE YUSHO AND YUCHENG RICE OIL POISONING INCIDENTS 521 Yoshito Masuda and Arnold Schecter 17 THE BINGHAMTON, NEW YORK, ELECTRICAL TRANSFORMER FIRE INCIDENT OF 1981 553 Nancy Kim and Arnold Schecter 18 THE YUSHCHENKO DIOXIN POISONING: CHRONOLOGY AND PHARMACOKINETICS 567 John Jake Ryan 19 POPs AND HUMAN HEALTH RISK ASSESSMENT 579 David T. Szabo and Anne E. Loccisano INDEX 619

About the Author

ARNOLD SCHECTER , MD, MPH, is Professor of Environmental and Occupational Health Sciences at the University of Texas School of Public Health. He is a preventive medicine physician-researcher who has studied the effects of dioxin and related chemical exposure around the world. Most recently, his research has focused on emerging POPs and endocrine disruptors in human milk, blood, and food. Dr. Schecter has served on EPA dioxin advisory panels and ATSDR/CDC dioxin, PCB, and PCDF review groups. Moreover, he has worked with the NIEHS, NIH, and NTP to communicate dioxin carcinogenicity assessments.

Reviews

"I would also consider it suitable as an advanced text for learning form as it indicates the range of information that has to be examined when making toxicological judgements which affect political decisions, including judgements that have to be taken in the face of pressure from lobbyists." ( British Toxicology Society New , 1 November 2012)