Table of Contents

Preface to the third edition 7 Acknowledgements to the third edition 7 Figure key 8 SI/mass unit conversions 9 Part 1 Acids, bases and pH 1 Acids, bases and hydrogen ions (protons) 10 2 Understanding pH 12 3 Production and removal of protons into and from the blood 14 4 Metabolic alkalosis and metabolic acidosis 16 5 Respiratory alkalosis and respiratory acidosis 18 Part 2 Structure of amino acids and proteins 6 Amino acids and the primary structure of proteins 20 7 Secondary structure of proteins 22 8 Tertiary and quaternary structure and collagen 24 Part 3 Formation of ATP: oxidation and reduction reactions 9 Oxidation/reduction reactions, coenzymes and prosthetic groups 26 10 Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction 28 11 Aerobic production of ATP 30 12 Biosynthesis of ATP by oxidative phosphorylation I 32 13 Biosynthesis of ATP by oxidative phosphorylation II 34 14 What happens when protons or electrons leak from the respiratory chain? 36 15 Free radicals, reactive oxygen species and oxidative damage 38 16 Aerobic oxidation of glucose to provide energy as ATP 40 17 Anaerobic oxidation of glucose by glycolysis to form ATP and lactate 42 18 Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect 44 Part 4 Carbohydrates 19 Carbohydrates 46 20 Absorption of carbohydrates and metabolism of galactose 48 21 Fate of glucose in liver: glycogenesis and lipogenesis 50 22 Fructose metabolism 52 23 Glucose homeostasis 54 24 Glucose-stimulated secretion of insulin from beta-cells 56 25 Regulation of glycogen metabolism 58 26 Glycogen breakdown (glycogenolysis) and glycogen storage diseases 60 27 Insulin signal transduction and diabetes mellitus 62 28 Diabetes mellitus 64 29 Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis 66 Part 5 Enzymes and regulation of pathways 30 Enzymes: nomenclature, kinetics and inhibitors 68 31 Regulation of enzyme activity 70 32 Regulation of glycolysis and Krebs cycle 72 33 Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver 74 34 Regulation of lipolysis, beta-oxidation, ketogenesis and gluconeogenesis 76 Part 6 Lipids and lipid metabolism 35 Structure of lipids 78 36 Phospholipids I: phospholipids and sphingolipids 80 37 Phospholipids II: micelles, liposomes, lipoproteins and membranes 82 38 Metabolism of carbohydrate to cholesterol 84 39 VLDL and LDL metabolism I: "forward" cholesterol transport 86 40 VLDL and LDL metabolism II: endogenous triacylglycerol transport 88 41 HDL metabolism: "reverse" cholesterol transport 90 42 Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons 92 43 Steroid hormones: aldosterone, cortisol, androgens and oestrogens 94 Part 7 Metabolism of amino acids and porphyrins 44 Urea cycle and overview of amino acid catabolism 96 45 Non-essential and essential amino acids 98 46 Amino acid metabolism: to energy as ATP; to glucose and ketone bodies 100 47 Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism 102 48 Phenylalanine and tyrosine metabolism in health and disease 104 49 Products of tryptophan and histidine metabolism 106 50 Haem, bilirubin and porphyria 108 Part 8 Vitamins 51 Fat-soluble vitamins I: vitamins A and D 110 52 Fat-soluble vitamins II: vitamins E and K 112 53 Water-soluble vitamins I: thiamin, ribofl avin, niacin and pantothenate 114 54 Water-soluble vitamins II: pyridoxal phosphate (B6) 116 55 Water-soluble vitamins III: folate and vitamin B12 118 56 Water-soluble vitamins IV: biotin and vitamin C 120 Part 9 Molecular biology 57 The cell cycle 122 58 Pyrimidine metabolism 124 59 Purine metabolism 126 60 Structure of DNA 128 61 The "central dogma" of molecular biology 130 62 Organisation of DNA in chromosomes 132 63 Replication of DNA (part 1) 134 64 Replication of DNA (part 2) 136 65 DNA damage and repair 138 66 Transcription of DNA to make messenger RNA (part 1) 140 67 Transcription of DNA to make messenger RNA (part 2) 142 68 Transcription of DNA to make transfer RNA 144 69 Transcription of DNA to make ribosomal RNA 146 70 Translation and protein synthesis 148 71 Comparison of DNA replication, DNA transcription and protein synthesis in eukaryotes and prokaryotes 150 Part 10 Diagnostic clinical biochemistry 72 Diagnostic clinical biochemistry (with Dr J. W. Wright FRCP, MRCPath) 152 Index 154

About the Author

J. G. Salway is the author of Medical Biochemistry at a Glance, 3rd Edition, published by Wiley.

Reviews

"It will also be essential reading for those preparing for professional qualifications such as FIBMS and FRCPath, possibly even MRCP, and will serve as an excellent resources for the more senior researcher, lecturer and academic." (The Bulletin of The Royal College of Pathologists, 1 January 2013) "It will also be essential reading for those preparing for professional qualifications such as FIBMS and FRCPath, possibly even MRCP, and will serve as an excellent resources for the more senior researcher, lecturer and academic." (The Bulletin of The Royal College of Pathologists, 1 January 2013) Clinical Pathology for the Veterinary Team will help experienced veterinary technicians set up various clinical laboratory diagnostic tests. It provides a good explanation of basic laboratory practices, the underlying concepts of many laboratory tests, and the physiology of common disease conditions. This book is well worth the price. (Journal of the American Veterinary Medical Association, December 2010) This book provides a good overall summary of basic clinical pathology in small animals. Although it is fairly short and concise, it contains all the necessary relevant information and includes a CD that takes readers thorough six complicated cases, step by step. This is a useful book that would be a handy reference to have in a practice. It is easy to read, concise, and informative. Although it is aimed at small animal veterinary teams, it includes limited information about large animal species, which is important for a good, general understanding. (Doodys, December 2010) Clinical Pathology for the Veterinary Team offers a fine recourse for technical team members involved in clinical diagnostic evaluation. Machinery calibration, normal anatomy, clinical diagnostics and more are revealed in chapters that provide key technical information for Obtaining and evaluating samples, surveying the disease process, the progress of identification and treatment, and including a DVD with interactive cases. Vet collections need this! (THE MIDWEST BOOK REVIEW, November 2010) Rosenfeld, a veterinarian who is associated with an education corporation that specializes in seminar training for the hospital team, and Dial (veterinary science and microbiology, U. of Arizona) provide a resource for technical veterinary team members performing clinical diagnostic evaluation in small animal lab work. (Book News, September 2010) ReviewUpdater-Profile_27@1326747466735