Table of Contents

List of Contributors vii

Preface ix

Foreword xiii
Ada Yonath

1 Molecular Mechanisms of Antibiotic Resistance – Part I 1
Alison J. Baylay, Laura J.V. Piddock, and Mark A. Webber

2 Molecular Mechanisms of Antibiotic Resistance – Part II 27
Liam K.R. Sharkey and Alex J. O’Neill

3 Resistance to Glycopeptide Antibiotics 51
François Lebreton and Vincent Cattoir

4 Resistance and Tolerance to Aminoglycosides 81
Wendy W.K. Mok and Mark P. Brynildsen

5 Tetracyclines: Mode of Action and their Bacterial Mechanisms of Resistance 101
Marilyn C. Roberts

6 Fluoroquinolone Resistance 125
Karl Drlica, Xilin Zhao, Muhammad Malik, Hiroshi Hiasa, Arkady Mustaev, and Robert Kerns

7 Dihydropteroate Synthase (Sulfonamides) and Dihydrofolate Reductase Inhibitors 163
Clemente Capasso and Claudiu T. Supuran

8 Anti‐tuberculosis Agents 173
Ying Zhang

9 Multidrug Resistance 201
Robert L. Marshall and Vassiliy N. Bavro

10 Anti‐virulence Therapies Through Potentiating ROS in Bacteria 239
Kristin J. Adolfsen and Mark P. Brynildsen

Index 255

About the Author

BOYAN B. BONEV is Associate Professor in Biophysics and Structural Biology, Faculty of Medicine & Health Sciences, University of Nottingham, UK. Dr. Bonev heads the Biomembrane NMR labs and is co-Director of the Dynamic Nuclear Magnetization Facility.

NICHOLAS M. BROWN is clinical lead for medical microbiology at Addenbrooke's Hospital, Cambridge. He is previous President and current Director of Public and Professional Engagement, British Society for Antimicrobial Chemotherapy (BSAC).