Preface xi
List of contributors xiii
Acknowledgements xv
1 Why clinicians should love neuroscience: the clinical
relevance of contemporary knowledge 1
David Wood
1.1 Introduction 1
1.2 The legacy of mind–body dualism 2
1.3 Free will and determinism 3
1.4 Clinical implications 3
1.5 Restriction of energy intake and increase in energy output 4
1.6 Non-eating-related concerns 5
1.7 In-the-beginning questions: the problem of aetiology in eating disorders 6
1.8 The temporal, ‘vertical’ aetiological dimension 7
1.9 The spatial, ‘horizontal’ aetiological dimension 11
1.10 The importance of a neuroscientific aetiological framework 13
1.11 Conclusion 15
References 16
2 Eating disorders: an overview 19
Beth Watkins
2.1 Introduction 19
2.2 Clinical descriptions 20
2.3 Comorbidity 24
2.4 Epidemiology 25
2.5 Aetiology and risk factors 27
2.6 Treatment 35
2.7 Course and outcome 40
2.8 Conclusion 41
References 41
3 Neuroimaging 56
Tone Seim Fuglset and Ian
Frampton
3.1 Introduction 56
3.2 Structural imaging 56
3.3 Functional imaging 90
3.4 Conclusion 101
References 101
4 Neuropsychology 106
Joanna E. Steinglass and
Deborah R. Glasofer
4.1 Introduction 106
4.2 Intellectual functioning 107
4.3 Attention 108
4.4 Memory 110
4.5 Visuospatial processing 111
4.6 Executive functioning 113
4.7 Conclusion 116
References 117
5 Neurochemistry: the fabric of life and the fabric of eating
disorders 122
Kenneth Nunn
5.1 Introduction 122
5.2 Five aims 122
5.3 Five propositions relating neurochemistry to the field of eating disorders 123
5.4 Five implications of these propositions 127
5.5 Five directions for future research 127
5.6 Conclusion 127
Acknowledgement 128
References 128
6 Body-image disturbance 129
Maria Øver°as
6.1 Introduction 129
6.2 What is body image? 130
6.3 How is body image constructed in the brain? 130
6.4 Body-image disturbance in eating disorders 133
6.5 The neuroscience of body-image distortion in anorexia nervosa 134
6.6 Conclusion 138
References 139
7 Conceptual models 142
Mark Rose and Ian
Frampton
7.1 Introduction 142
7.2 Conceptual models in anorexia nervosa 143
7.3 Conclusion 161
References 163
8 Towards a comprehensive, causal and explanatory
neuroscience model of anorexia nervosa 164
Kenneth Nunn,
Bryan Lask and Ian Frampton
8.1 Introduction 164
8.2 The model 164
8.3 Critical appraisal 173
8.4 Clinical implications 175
8.5 Conclusion 177
Acknowledgements 177
References 177
9 Neurobiological models: implications for patients and
families 180
Ilina Singh and Alina Wengaard
9.1 Introduction 180
9.2 The emergence of neurobiological models 180
9.3 Anorexia nervosa and illness representations 181
9.4 Impact of a neurobiological model on families’ understandings of anorexia nervosa 183
9.5 Conclusion 188
References 189
10 Implications for treatment 191
Camilla Lindvall
and Bryan Lask
10.1 Introduction 191
10.2 Psychopharmacology 192
10.3 The educational context 193
10.4 Psychological treatment 194
10.5 Conclusion 205
References 205
11 Future directions 207
Ian Frampton and Bryan
Lask
11.1 Introduction 207
11.2 Cause 207
11.3 Assessment and diagnosis 208
11.4 Treatment 210
11.5 Prevention 211
11.6 Future directions 212
11.7 Conclusion 215
References 216
Index 219
Bryan Lask FRCPsych, FAED, M.Phil, MB,. BS
Hon Consultant and Emeritus Professor of Child and Adolescent
Psychiatry, Great Ormond Street Hospital for Children, London, UK;
Research Director, Ellern Mede Service for Eating Disorders,
London, UK; Visiting Professor, Oslo University Hospital,
Norway
Ian Frampton BA(Hons) D.Clin.Psych. Dip.Clin.Neuropsych.
C Psychol.
Hon Consultant Psychologist, Great Ormond Street Hospital for
Children, London, UK; Visiting Research Consultant, Regional Eating
Disorders Service, Oslo University Hospital, Norway
"Congratulation on excellent book: informative, readable, broad in
its coverage, and very useful to those of us who are not
neuroscientists.I particularly appreciated the several concluding
chapters that articulated and evaluated the nature, strengths, and
shortcomings of models."
(Dr Michael Levine, Emeritus Professor of Psychology, Kenyon
College, Gambier, USA, November 2102)
“This is a very good contribution to the psychiatric literature
that will help clinicians, researchers, and neuroscientists in
general to understand eating disorders from a biopsychosocial
perspective. It gives a very explicit definition of eating
disorders as well as treatment options and future overviews.”
(Doody's, 25 May 2012) "Well written and well edited, nicely
balanced between academic reviews and integrative theoretical
syntheses, the readable chapters will inform readers who lack deep
knowledge about biological aspects of eating disorders as well as
those who are better informed. Chapters are scholarly without being
stuffy, and contributors summarize pertinent studies in structural
and functional neuroimaging, neuropsychology, and the neuroscience
of body image.
For serious eating disorders clinicians as well as academicians,
there’s much in this book to study and ponder." - EATING DISORDERS
REVIEW
“There has been an important paradigm shift in thinking about
eating disorders in that the brain is receiving more
attention. The Academy of Eating Disorders has published a
position paper placing the brain more centrally within these highly
complex multifaceted disorders. This book is an important
addition to the literature: the authors are all expert
communicators and are able to make the topic simple,
enjoyable and easy to understand.” - Janet Treasure,
Professor of Psychiatry, Guy’s, King’s & St Thomas’ Medical School,
London, UK
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