Table of Contents

– Creatine: Cheap Ergogenic Supplement with Great Potential for Health and Disease.- Early Evolution of the Creatine Kinase Gene Family and the Capacity for Creatine Biosynthesis and Membrane Transport.- The Creatine Kinase Phosphotransfer Network: Thermodynamic and Kinetic Considerations, the Impact of the Mitochondrial Outer Membrane and Modelling Approaches.- Expression and Function of Agat, Gamt and CT1 in the Mammalian Brain.- A Novel Relationship Between Creatine Transport at the Blood-Brain and Blood-Retinal Barriers, Creatine Biosynthesis, And its Use for Brain and Retinal Energy Homeostasis.- Functional Insights into the Creatine Transporter.- In Vivo Magnetic Resonance Spectroscopy of Transgenic Mice with Altered Expression of Guanidinoacetate Methyltransferase and Creatine Kinase Isoenzymes.- Cerebral Creatine Deficiency Syndromes: Clinical Aspects, Treatment and Pathophysiology.- Pre-Symptomatic Treatment of Creatine Biosynthesis Defects.- Clinical Use of Creatine in Neuromuscular and Neurometabolic Disorders.- The Neuroprotective Role of Creatine.- Ergogenic Effects of Creatine in Sports and Rehabilitation.- Pharmacokinetics of Creatine.- Safety of Creatine Supplementation.- Creatine – its Chemical Synthesis, Chemistry, and Legal Status.- Creatine and Creatine Kinase in Health and Disease – A Bright Future Ahead?.