I. Genetics: Genetics
II. Embryology: Embryology . Regulation of Embryogenesis .
Pathophysiology of Congenital Malformations
III. The Placenta: Placental Development . Regulation of the
Placental Circulation . Mechanisms of Transfer Across the Human
Placenta . Endocrine and Paracrine Function of the Human Placenta .
Placental Proteins . Placental Separation at Birth . Multiple
Pregnancy
IV. Developmental Pharmacology and Pharmacokinetics: Basic
Pharmacologic Principles . Basic Pharmacokinetic Principles .
Physiochemical and Structural Properties Regulating Placental Drug
Transfer . Genetic Regulation of Drug Metabolism . Drug
Distribution During Fetal Life . Drug Protein Binding During
Development . Development of Renal Excretion of Drugs During
Ontogeny . Pharmacodynamics and Receptor Sensitivity During
Development . Drug Abuse During Fetal and Neonatal Life .
Sympathoadrenal Mechanisms During Development . Developmental
Neuropharmacology . Physiologic Differences of Clinical
Significance . Therapeutic Drug Monitoring in the Newborn . Drug
Excretion during Lactation
V.Intrauterine Growth: Intrauterine Growth and Nutrition
VI. Postnatal Growth and Nutrition: Infant Growth in the First Year
of Life . Endocrine and Other Factors Affecting Growth . Water
Requirements . Energy Requirements . Protein Requirements .
Carbohydrate Requirements . Fat Metabolism and Requirements .
Mineral and Trace Element Requirements . Vitamin Requirements .
Human Milk Composition and Function in the Infant . Types and
Methods of Feeding for Infants . Nutritional Assessment . Growth
Outcome of Critically Ill Neonates
VII. Perinatal Iron, Trace Minerals, and Vitamin Metabolism: Iron
Metabolism during Fetal and Neonatal Life . Trace Element
Metabolism in the Fetus and Neonate . Metabolism of Vitamin A and
Water Soluble Vitamins During Fetal and Neonatal Life . Vitamin E
Metabolism in the Fetus and Neonate . Vitamin K Metabolism during
the Fetal and Neonatal Periods
VIII. Lipid Metabolism in the Fetus and Newborn: Placental
Transport of Free Fatty Acids, Glycerol, and Ketone Bodies . Lipid
Accretion in the Fetus and Newborn . Brown Adipose Tissue:
Development and Function . Lipids and an Energy Source for the
Premature and Full-Term Neonate . Ketone Body Production and
Metabolism in the Fetus and Newborn . Very Long Chain Fatty Acids
in the Developing Retina and Brain . Physiological Effects of Lipid
Infusions . Developmental Physiology of Lipoproteins and
Cholesterol . Lipoprotein Lipase
IX. Carbohydrate Metabolism: Metabolism of Glucose and Methods of
Investigation in the Fetus and Newborn . Maternal Metabolism During
Pregnancy . Carbohydrate Metabolism in the Fetus . Role of
Glucoregulatory Hormones on Hepatic Glucose Metabolism During the
Perinatal Period . Cell Glucose Transport and Glucose Handling
During Fetal and Neonatal Development . Glucose Metabolism During
the Transition to Postnatal Life . Hypoglycemia and Hyperglycemia
in the Newborn
X. Protein Metabolism: General Concepts of Protein Metabolism .
Fetal Requirements and Placental Transfer of Nitrogenous Compounds
. Nitrogen Sources for the Newborn . Protein Metabolism in the
Newborn . Protein and Amino Acid Requirements . Modification of
Protein Metabolism Because of Disease
XI. Thermoregulation: Perinatal Thermal Physiology . Neonatal
Thermal Physiology . Physics and Physiology of Human Incubation .
Temperature Measurement in the Preterm Newborn . Incubator
Management
XII. Skin: Structural and Biochemical Organogenesis of Skin and
Cutaneous Appendages in the Fetus and Newborn . Development of the
Cutaneous Circulation . Composition of Skin Lipids . Sweating in
the Neonate . pH Patterns in Newborn Skin . Skin Barrier Function .
Bacterial Colonization of the Skin of the Newborn
XIII. Fetal and Neonatal Cardiovascular Physiology: Development of
the Fetal Heart . Molecular Development of the Heart . Role of
Peptide Growth Factors in Cardiovascular Development . Fetal and
Neonatal Cardiovascular Physiologic Development . Developmental
Electrophysiology in the Fetus and Neonate . Developmental Biology
of the Pulmonary Vasculature . Development of the Pulmonary
Circulation: Metabolic Aspects . Development of the
Gastrointestinal Circulation in the Fetus and Newborn . Regulation
of the Fetal Cerebral Circulation . Autonomic and Central
Neuroregulation of Fetal Cardiovascular Function . Endocrine
Regulation of the Fetal Circulation . Nitric Oxide and the
Perinatal Circulation . Regulation of Umbilical Blood Flow . Fetal
and Placental Circulation During Labor . Cardiovascular Diagnosis
in the Fetus and the Effects of Congenital Heart Lesions on
Developing Physiology . Response of the Fetal Circulation to Stress
. Fetal and Neonatal Congestive Heart Failure . Physiology of
Resuscitation
XIV. The Lung: Normal and Abnormal Structural Development of the
Lung . Fetal and Neonatal Lung-liquid Balance . Functional
Development of the Upper Airway . Functional Development of the
Lower Airway . Functional Development of Respiratory Muscles .
Mechanics of Breathing . Pulmonary Gas Exchange in the Developing
Lung . Oxygen Transport and Delivery . Control of Breathing in
Fetal Life and Onset and Control of Breathing in the Neonate .
Pathophysiology of Apnea of Prematurity . Evaluation of Pulmonary
Function in the Neonate . Pathophysiology of Hyaline Membrane
Disease (Excluding Surfactant) . Pathophysiology of Lung Injury and
Repair: Special Features of the Immature Lung . Pathophysiology of
Chronic Lung Disease . Physiologic Effects of Conventional
Mechanical Ventilation . Physiology of High Frequency Ventilation .
Liquid Ventilation . Physiology of Extracorporeal Membrane
Oxygenation
XV. Pulmonary Surfactant: Historical Perspective . Composition of
Pulmonary Surfactant Lipids and Proteins . Biophysical Activities
of Pulmonary Surfactant . Lung Morphogenesis: Formation and
Function of the Alveolar Surface Layer . Regulation of
Surfactant-associated Phospholipid Synthesis and Secretion .
Pathophysiology of Respiratory Distress Syndrome . Hormonal Therapy
for Prevention of Respiratory Distress Syndrome . Surfactant
Replacement Therapy
XVI. Physiology Of The Gastrointestinal Tract in the Fetus and
Neonate: Cellular and Molecular Aspects of Human Gastrointestinal
Development . Organogenesis, Innervation, and Histologic
Development of the Gastrointestinal Tract . Development of the
Enteric Nervous System . Development of Gastric Secretory Function
. Development of Intestinal and Colonic Motility . Motility of the
Upper Gastrointestinal Tract in the Fetus and Neonate . Development
of Exocrine Pancreatic Function . Digestive and Absorptive Function
in the Fetus and Infant . Pathophysiology of Gastroesophageal
Reflux . Pathophysiology and Epidemiology of Necrotizing
Enterocolitis
XVII. Liver and Bilirubin Metabolism: Organogenesis and Histologic
Development of the Liver . Fetal and Postnatal Hepatic Vasculature
and Blood Flow . Bile Acid Metabolism during Development . Bile
Secretion and its Control in the Mature and Immature Organism .
Hepatic Disposition of Xenobiotics during Prenatal and Early
Postnatal Development . Bilirubin Metabolism and Toxicity in the
Newborn . Pathophysiology of Breast-Milk Jaundice . Phototherapy
for Neonatal Jaundice . Pathophysiology of Metabolic Diseases of
the Liver . Pathogenesis of Neonatal Cholestasis . Evaluation of
Liver Function
XVIII. The Kidney: Embryogenesis and Anatomic Development of the
Kidney . Renal Function in Utero . Postnatal Maturation of Renal
Blood Flow . Development of the Renin-Angiotensin System .
Postnatal Development of Glomerular Filtration . Measurement of
Glomerular Filtration Rate in Neonates . Renal Transport of Sodium
During Early Development . Potassium Transport in Early Development
. Transport of Calcium and Phosphorus . Transport of Amino Acids
During Early Development . Developmental Aspects of Organic Acid
Transport . Concentration of the Urine . Dilution of the Urine .
Urinary Acidification . The Response to Nephron Loss in Early
Development . Regulation of Blood Pressure During Fetal and Newborn
Life . Clinical Significance of Developmental Renal Physiology .
Pathophysiology of Acute Renal Failure in the Neonatal Period .
Continuous Hemofiltration in Neonates
XIX. Fluid and Electrolyte Metabolism: Fluid Distribution in the
Fetus and Neonate . Fetal and neonatal Body Fluid Composition with
Reference to Growth and Development . Colloid Pressure and
Osmoregulation in the Pregnant Woman, Fetus, and Neonate .
Regulation of Acid-Base Balance in the Fetus and Neonate . Hydrops
Fetalis and Other Causes of Neonatal Edema and Ascites
XX. Hematopoiesis and Granulopoiesis: Developmental Biology of the
Hematopoietic Growth Factors . Developmental Granulopoiesis .
Developmental Erythropoiesis . Developmental
Megakaryocytopoiesis
XXI. Hemostasis: Normal Hemostasis in the Newborn: Plasmatic
Factors . Normal Hemostasis in the Newborn: Cellular Factors,
Platelets, and the Vessel Wall . Pathophysiology of Bleeding
Disorders in the Newborn . Pathophysiology of Neonatal Disseminated
Intravascular Coagulation and Thrombosis
XXII. Developmental Immunobiology: Host Defense Mechanisms Against
Bacteria, Fungi, Viruses, and Nonviral Intracellular Pathogens .
T-Cell Development . B-Cell Development . Mononuclear Phagocyte
System . Neutrophil Function in Newborn Infants . The Complement
System in the Fetus and Newborn . Cytokines and the Inflammatory
Response . Integrins and Cell Adhesion Molecules .
Stimulus-Response Coupling . Fetal and Neonatal Wound Healing .
Immunology of the Breast and Host Immunity . Amniotic Fluid Host
Defense Mechanisms . Host Defense Mechanisms in the Lung
XXIII. Neurology: Development of the Nervous System . Development
of the Blood-Brain Barrier . Development of Neurotransmitters .
Biochemistry of Hypoxic-ischemic Brain Injury . Perinatal Brain
Metabolism and Prevention of Asphyxial Injury . Developmental
Biochemistry: Studies in vivo with Nuclear Magnetic Resonance
Spectroscopy . Electroencephalography in the Premature and
Full-term Infant . Development of Tone and Reflexes in the Fetus
and Newborn . Cerebral Blood Flow in Premature Infants: regulation,
Measurement, and Pathophysiology of Intraventricular Hemorrhage .
Intraventricular Hemorrhage in the Premature Infant: Morphologic
Characteristics . Deleterious Effects of Intrauterine Drug Exposure
of the Nervous System . Nutritional and Hormonal Regulation of
Brain Development . Ontogenesis of Striated Muscle
XXIV. Special Sensory Systems in the Fetus and Neonate: Development
of Touch, Pain, and Temperature Sensation in the Fetus and Neonate
. Anatomical and Functional Development of the Eye and
Pathophysiology of Retinopathy of Prematurity . Anatomical and
Functional Development of Hearing . Development of Taste and Smell
in the Neonate
XXV. Calcium, Phosphorus, and Magnesium Metabolism:
Calcium-Regulating Hormones . Calcium, phosphorus, and Magnesium
Transport Across the Placenta . Neonatal Calcium, Phosphorus, and
Magnesium Homeostasis . Pathophysiology of Neonatal Hypocalcemia .
Osteopenia of Rickets of Prematurity
XVI. Orthopedics: Growth Plate: Structure and Physiology .
Intrauterine Compression Syndromes: Effects of Mechanics on
Endochondral Ossification . Defective Limb Embryology . Congenital
Vertebral Anomalies and their Sequelae . The Congenital Muscle
Diseases . Skeletal Dysplasia and Dwarfism: Physiology and
Pathophysiology . Pathophysiology of Neonatal Osteomyelitis and
Septic Arthritis . Standards and Measurements: Fetus and
Neonate
XVII. The Pituitary: Neurosecretions and Neurotransmitters of the
Fetal Hypothalamus . Growth Factors and Development . Growth
Hormone and Prolactin . LH and FSH Secretion in the Fetus and
Newborn . Development of the Corticotropin-releasing Factor
ACTH/Beta Endorphin System in the Mammalian Fetus . Fetal and
Neonatal Neuropophyseal Hormones
XXVIII. The Fetal and Neonatal Adrenal and Fetal Thyroid Systems:
Fetal and Neonatal Adrenocortical Physiology . Fetal and Neonatal
Thyroid Physiology
XXIX. The Ovary and Testis: Sex Determination . Germ Cells and the
Indifferent Gonad . Differentiation of the Ovary . Testicular
Development . Testicular Descent
Index
"This is the gold standard reference for fetal and neonatal physiology and developmental biology. While it may not be in every clinician's personal library, it should be available to every clinician for reference when needed. There is no comparable comprehensive book."-Jay P. Goldsmith, MD(Tulane University School of Medicine) Doody Review: 4 stars
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