Table of Contents

Introduction to Tuberculosis; The global problem; History of tuberculosis; Overview of clinical tuberculosis, Epidemiology of tuberculosis; Current laboratory diagnosis of tuberculosis; Animal models of tuberculosis; Biohazard considerations; Mycobacteriophages; Plasmids; Transposons, insertion elements and restriction polymorphisms; Approach to genomic structure; Expression of foreign genes in mycobacteria; Genetic strategies for analyzing virulence; The Physiology of M tuberculosis; Ultrastructure; Lipids and carbohydrates of M tuberculosis; Proteins and antigens of M tuberculosis; Metabolism of M tuberculosis; Transport in M tuberculosis; The Immunology of Tuberculosis; Immune mechanisms of protection; T cell responses and lymphokines; B and T cell recognition; Pathogenesis of tuberculosis; Pathogenesis of tuberculosis in AIDS; New Approaches to Prevention and Treatment of Tuberculosis; Molecular approaches to diagnosis; BCG and new approaches to vaccines for tuberculosis; Search for new drugs; Molecular epidemiology; Operational and economic issues; Cultivation of M tuberculosis