Table of Contents

Volume I Molecular Biology


Part I The Science of Virology


1 Foundations


2 The Infectious Cycle


Part II Molecular Biology


3 Genomes and Genetics


4 Structure


5 Attachment and Entry


6 Synthesis of RNA from RNA Templates


7 Reverse Transcription and Integration


8 Synthesis of RNA from DNA Templates


9 Replication of DNA Genomes


10 Processing of Viral Pre-mRNA


11 Protein Synthesis


12 Intracellular Trafficking


13 Assembly, Exit, and Maturation


14 The Infected Cell


Appendix Structure, genome organization, and infectious cycles


Glossary


Index


Volume II Pathogenesis and Control


1 Infections of Populations: History and Epidemiology


2 Barriers to Infection


3 The Early Host Response: Cell-Autonomous and Innate Immunity


4 Adaptive Immunity and the Establishment of Memory


5 Mechanisms of Pathogenesis


6 Cellular Transformation and Oncogenesis


7 Human Immunodeficiency Virus Pathogenesis


8 Vaccines


9 Antiviral Drugs


10 Evolution  


11 Emergence


12 Unusual Infectious Agents


Appendix Diseases, Epidemiology, and Disease Mechanisms of Selected Animal Viruses Discussed in This Book


Glossary


Index

About the Author

Jane Flint is a Professor of Molecular Biology at Princeton University. Dr. Flint's research focuses on investigation of the molecular mechanisms by which gene products of adenoviruses modulate host cell pathways and anti-viral defenses to allow efficient reproduction in normal human cells. Vincent Racaniello is Higgins Professor of Microbiology & Immunology at Columbia University Medical Center. Dr. Racaniello has been studying viruses for over 35 years, including poliovirus, rhinovirus, enteroviruses, and hepatitis C virus. Dr. Racaniello blogs about viruses at virology.ws and is host of the popular science program This Week in Virology.

Reviews

"Principles of Virology is an extremely valuable and highly informative textbook that describes virology at the interface of modern cell biology. Instead of teaching virus groups individually, the authors elegantly compile the molecular and cell biological aspects that orchestrate virus replication in general and how infections with these pathogens cause cell damage and diseases. As a teacher of Master students in Biosciences and in human medicine, I highly recommend this textbook." ─ Ralf Bartenschlager, Department Head and Professor, Molecular Virology, University of Heidelberg