Table of Contents

Preface. Foreword, Acknowledgments, Introduction and general considerations: Malaria parasite lifecycle. Clinical manifestations. Pathology and pathogenesis. General history of malaria: Malaria in the ancient world. Malaria in the pre-Columbian America. Illustrations. From swamp fever to the malaria parasite: Malaria: the name and its origin. Melanemia. Animacular theory: Contagium vivum. The cause of malaria: the malarial parasite. The transmission of malaria: The precursors. The mosquito vector. The role of the mosquito in the transmission of malaria. The controversy: a matter of priority. Illustrations. Treatment of malaria: Treatment of malaria before the Peruvian bark and quinine. Pre-Columbian uses of cinchona bark. The Spanish and European traditions. The use of cinchona bark and quinine in North America. The cinchona tree. The cultivation of the cinchona tree. Quinine. Synthetic anti-malarials. Illustrations. Malaria prevention: Protection against mosquitoes. Cinchona bark and quinine prophylaxis. The unsolved problems of malaria prevention. Illustrations. The impact of malaria. Bibliography. Names and dates. Index.