Table of Contents

Preface.List of Contributors.Abbreviations.1 Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10 (Alan M. Gruenberg, Reed D. Goldstein and Harold Alan Pincus).2 Psychosocial and Environmental Formulations of Depression (Gordon Parker and Kay Parker).3 The Economic Burden of Depression: Societal and Patient Perspectives (Paul E. Greenberg and Howard G. Birnbaum).4 The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions (Hagop S. Akiskal and Lewis L. Judd).5 The Monoamine Hypothesis of Depression (Leslie Iversen).6 Monoaminergic-based Pharmacotherapy for Depression (George I. Papakostas and Maurizio Fava).7 Psychobiology of Electroshock (Max Fink).8 Current Prognosis of Depression (H. Brent Solvason and Alan Schatzberg).9 Treatment of Depression in Medical Illness (Charles L. Raison, David C. Purselle, Lucile Capuron and Andrew H. Miller).10 Depression and Suicidality in Children and Adolescents (Cynthia R. Pfeffer).11 The Biology and Genetics of Suicidality (Gustavo Turecki and Aleksandra Lalovic).12 Geriatric Depression (Bindu Shanmugham and George Alexopoulos).13 Comorbidity of Depression and Substance Abuse (Edward V. Nunes and Wilfred N. Raby).14 Depression in the Context of Cancer (Elliot J. Coups, Jeremy Winell and Jimmie C. Holland).15 Treatment of Refractory Depression (Michael Gitlin).16 Clinical Pharmacology of New Classes of Antidepressant Drugs (Justine M. Kent).17 Neuroimaging and Neuropathological Studies of Mood Disorders (Wayne C. Drevets and Joseph L. Price).18 Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms (Blynn G. Bunney, Steven G. Potkin and William E. Bunney).19 Neuropeptidergic Dysfunction in Depression (Garth Bissette).20 Depression, Mania, and Thyroid Function: A Story of Intimate Relationships (Peter C. Whybrow and Michael Bauer).21 Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities (P. W. Gold).22 Neuroimmune Mediators: Are Cytokines Mediators of Depression? (Renaud de Beaurepaire, Artur H. Swiergiel and Adrian J. Dunn).23 Borna Disease Virus: Impact on Mood and Cognition (Liv Bode, Detlef E. Dietrich and Hanns Ludwig).24 Depression and Heart Disease (Robert M. Carney and Kenneth E. Freedland).25 Genetic Substrates Shared by Depression and Cardiovascular Disease (Brigitta Bondy).26 History and Epidemiology of Depression (Ma-Li Wong).27 Major Depression and Animals Models (Ma-Li Wong).28 Loss and Deprivation: From Animal Models to Clinical Presentation (Kristin M. Penza, Christine Heim and Charles B. Nemeroff).29 Neurogenomics of depression (Klaus Peter Lesch).30 Genetic Approaches to Depression: Linkage Studies (Francis M. Mondimore and James B. Potash).31 Genetic Approaches to Depression: Association Studies (Kopal Tandon and Katherine J. Aitchison).32 Molecular Effects of Antidepressant Treatments (Pierre Sokoloff).33 The Role of Transcription Factors in the Biology of Depression (Robert D. Beech and Ronald S. Duman).34 Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action (Ma-Li Wong).35 Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications (Adrian Llerena).36 Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response (Kristopher J. L. Irizarry).37 Emerging Treatments for Depression: Beyond the Monoamine Hypothesis (Julio Licinio).38 Antidepressants and Suicide: Clinical Considerations (Julio Licinio).39 Depression in Developing Countries (Mauricio Silva de Lima and Bernardo Garcia de Oliveira Soares).40 Complementary and Alternative Medical Treatment for Depression (Peter B. Bongiorno).41 The Experience of Depression (Susan Blauner, Catherine Bond, Philip J. Burguieres, Ma-Li Wong, Julio Licinio, and Deborah L. Flores).Subject Index.

About the Author

Professor Ma-Li Wong, Co-Director of the Center for Pharmacogenomics & Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in neurology at the University of Sao Paulo, Brazil and psychiatry at the Albert Einstein College of Medicine, New York, and at Yale University. She joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Molecular Neuroendocrinology Unit, Clinical Neuroendocrinology Branch. In 1999 she took up a professorship at the UCLA Department of Psychiatry & Biobehavioral Sciences, later becoming Director of its Neuroendocrine Core, and has been Director of the General Clinical Research Center Core Laboratory since 2002. Her current research focuses on the genomics and genetics of antidepressant treatment. Professor Wong is Associate Editor of Molecular Psychiatry. Professor Julio Licinio, Co-Director of the Center for Pharmacogenomics & Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in medicine at the University of Sao Paulo, Brazil, endocrinology at the University of Chicago, and psychiatry at Cornell University and Yale University and joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Clinical Research Unit, Clinical Neuroendocrinology Branch. In 1999 he came to UCLA as Professor of Psychiatry & Biobehavioral Sciences and Medicine/Endocrinology. He is Founding President of the International Society of Pharmacogenomics and one of the principal investigators in the NIH Pharmacogenetics and Pharmacogenomics Research Network. His main research interests include the role of leptin in neuroendocrine-immune interactions and pharmacogenomics of antidepressants. Professor Licinio is Editor of The Pharmacogenomics Journal and Molecular Psychiatry.

Reviews

"...a great resource for professionals in the fields of psychiatry, psychology, social work, counseling and medicine who want a very comprehensive understanding of the disease...a truly necessary addition to libraries..." (E-STREAMS, April 2006) "Of its far-reaching boundaries and because we have not seen another book on this subject as detailed and well-organized; simply, everything the clinician needs to know in order to arrive at suitable treatment for the individual patient is contained on the pages of this handbook." (Electric Review, November/December 2005)