Table of Contents

1. Introduction and History 2. Developmental Biology of Erythropoiesis and Erythropoietin Production 3. Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia Dependent Genes 4. Physiology and Metabolism of Erythropoietin 5. Biochemistry and Protein Structure 6. Receptor Biology and Signal Transduction 7. Clinical Disorders of Erythropoietin and its Receptor 8. Recombinant Erythropoietin and the Treatment of Anemia 9. Function of Erythropoietin Outside of Hematopoiesis 10. Erythropoietin and Sport 11. The Future of Erythropoietin

About the Author

Dr. Arthur Sytkowski received his Doctor of Medicine from the Medical College of Wisconsin and worked as a Research Associate in the Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda. In 1977, he joined Harvard Medical School, and established his research on the structure and function of human erythropoietin. Current research interests include therapeutic protein engineering, the control of blood cell differentiation, mechanisms of neoplasia, biological effects of microgravity, ligand/receptor biochemistry, growth factor signal transduction, gene regulation and cancer chemoprevention.

Reviews

"... in einem einzigen Buch den weiten Informationsbereich uber die Wirkweise und Anwendung von Erythropoietin komprimiert." Arzneimittel-Forschung